| SkyLink Data Center BV | SkyLink Data Center BV | Eygelshoven | Netherlands | 35 | 1 |
| SKYLINK DATA CENTERS | SKYLINK DATA CENTERS | Naples | United States | 2 | 0 |
| SkyOnLine | SkyOnline de Argentina S.A. | Buenos Aires | Argentina | 4 | 0 |
| SloughIX | Network-I | Slough | United Kingdom | 1 | 0 |
| Slovak University of Technology | Slovak University of Technology in Bratislava | Bratislava | Slovakia | 36 | 2 |
| Smart Burundi | Lacell SU | Bujumbura | Burundi | 0 | 0 |
| Smart City Telecom Maitland Colo | Smart City Telecom | Orlando | United States | 0 | 0 |
| SMART NETWORKS | SmartSat | Recife | Brazil | 2 | 1 |
| Smart Telecom Telecomunicações LTDA | 76 TELECOMUNICAÇÃO LTDA | São Paulo | Brazil | 3 | 0 |
| Smart Village Data Center (B90) | Telecom Egypt | Giza | Egypt | 2 | 0 |
| Smartcom Telephone (MCAL1) | Smartcom Telephone, LLC | McAllen | United States | 1 | 0 |
| Smartcom Telephone (MCAL2) | Smartcom Telephone, LLC | McAllen | United States | 0 | 0 |
| Smartdc Heerlen | Smartdc | Heerlen | Netherlands | 3 | 0 |
| Smartdc Montreal | Smartdc | Montreal | Canada | 1 | 0 |
| Smartdc Paris | Smartdc | Montreuil | France | 0 | 0 |
| Smartdc Rotterdam | Smartdc | Rotterdam | Netherlands | 30 | 5 |
| SmartHub Fujairah | Etisalat | Fujairah | United Arab Emirates | 51 | 3 |
| SMRWORXA - Somerset West Central Office | Ziply Fiber | Portland | United States | 2 | 1 |
| SOCO Datacenter | SOCO Network Solutions GmbH | Dueren | Germany | 2 | 0 |
| Sofia Data Center (SDC) | Neterra Ltd. | Sofia | Bulgaria | 40 | 5 |
| Sofia Data Center (SDC) 2 | Neterra Ltd. | Sofia | Bulgaria | 3 | 1 |
| Sofia Data Center (SDC) Ruse | Neterra Ltd. | Ruse | Bulgaria | 6 | 2 |
| Sofia Data Center (SDC) Stolnik | Neterra Ltd. | Stolnik | Bulgaria | 4 | 1 |
| SoftBank Tokyo No. 4 | Softbank Corp. | Tokyo | Japan | 1 | 1 |
| SOFTDADOS | MARKTEC TELECOM | Salvador | Brazil | 1 | 0 |
| Softdados Aracaju POP | Softdados Telecomunicações | Aracaju | Brazil | 1 | 0 |
| Softdados IDC | Softdados Telecomunicações | Salvador | Brazil | 3 | 0 |
| Softdados IDC at Telxius CLS | Softdados Telecomunicações | Salvador | Brazil | 3 | 0 |
| Softnet Koper DC | Softnet | Koper | Slovenia | 1 | 0 |
| Softnet Ljubljana DC | Softnet | Ljubljana | Slovenia | 1 | 0 |
| Softnet Trzin DC | Softnet | Trzin | Slovenia | 2 | 0 |
| Solcon Datacenter Dronten | Solcon Internetdiensten B.V. | Dronten | Netherlands | 2 | 0 |
| Soleblanca Datacenter | Soleblanca SA | Chiasso | Switzerland | 1 | 0 |
| Somme-numerique DC1 | Somme-numerique DC1 | Amiens | France | 2 | 0 |
| SONDA - Kudos | SONDA S.A. | Santiago | Chile | 3 | 1 |
| SONDA - Quilicura | SONDA S.A. | Santiago | Chile | 2 | 0 |
| SONDA - Teatinos | SONDA S.A. | Santiago | Chile | 3 | 0 |
| Soul DataCentre | Vocus Group | North Melbourne | Australia | 1 | 0 |
| South Reach Networks | South Reach Networks | Miami | United States | 8 | 3 |
| South Spencer Aureon hut | Aureon Network Services | Spencer | United States | 2 | 0 |
| South West Communications Exeter | South West Communications Group Ltd | Exeter | United Kingdom | 1 | 0 |
| Southern Telecom | Southern Telecom | Atlanta | United States | 1 | 0 |
| SouthTech Telecom - Porto Alegre | Vogel Soluções em Telecom e Informática S/A | Porto Alegre | Brazil | 4 | 1 |
| Southwest Cyberport Albuquerque | Southwest Cyberport, Inc. | Albuquerque | United States | 0 | 0 |
| SoVerNet Burlington | SoVerNet | Burlington | United States | 1 | 0 |
| SP4 | Entel S.A. - EntelNet | São Paulo | Brazil | 1 | 0 |
| Spaanse Kubus Rotterdam | TCNPP | Rotterdam | Netherlands | 16 | 2 |
| SPACE-IX | RECONN. Operator Svyazi, LLC | Moscow | Russia | 0 | 0 |
| SpaceNet (LA) | SpaceNet | Munich | Germany | 3 | 1 |
| SpaceNet Limited | SpaceNet Ltd. | Dhaka | Bangladesh | 1 | 0 |